Ontology highlight
ABSTRACT:
SUBMITTER: Gullbrand SE
PROVIDER: S-EPMC7380504 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Gullbrand Sarah E SE Ashinsky Beth G BG Bonnevie Edward D ED Kim Dong Hwa DH Engiles Julie B JB Smith Lachlan J LJ Elliott Dawn M DM Schaer Thomas P TP Smith Harvey E HE Mauck Robert L RL
Science translational medicine 20181101 468
Tissue engineering holds great promise for the treatment of advanced intervertebral disc degeneration. However, assessment of in vivo integration and mechanical function of tissue-engineered disc replacements over the long term, in large animal models, will be necessary to advance clinical translation. To that end, we developed tissue-engineered, endplate-modified disc-like angle ply structures (eDAPS) sized for the rat caudal and goat cervical spines that recapitulate the hierarchical structure ...[more]