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Moving out: from sterol transport to drug resistance - the ABCG subfamily of efflux pumps.

ABSTRACT: The ATP binding cassette (ABC) proteins are typically ATP-driven transmembrane pumps that have been evolutionarily conserved from bacteria to humans. In humans these transporters are subdivided into seven subfamilies, ranging from A to G. The ABCG subfamily of transporters is the primary focus of this review. This subfamily of proteins has been conserved throughout evolution and plays a central role in several cellular processes, such as sterol homeostasis and multidrug resistance. Functional polymorphisms/mutations in some of these G-subfamily transporters have clinical consequences in humans.

SUBMITTER: Moitra K

PROVIDER: S-EPMC7380564 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Moving out: from sterol transport to drug resistance - the ABCG subfamily of efflux pumps.

Moitra Karobi K Silverton Latoya L Limpert Katy K Im Kate K Dean Michael M

Drug metabolism and drug interactions 20110927 3

The ATP binding cassette (ABC) proteins are typically ATP-driven transmembrane pumps that have been evolutionarily conserved from bacteria to humans. In humans these transporters are subdivided into seven subfamilies, ranging from A to G. The ABCG subfamily of transporters is the primary focus of this review. This subfamily of proteins has been conserved throughout evolution and plays a central role in several cellular processes, such as sterol homeostasis and multidrug resistance. Functional po ...[more]

PMID: 21942345

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