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Comparisons between dipeptidyl peptidase-4 inhibitors and other classes of hypoglycemic drugs using two distinct biomarkers of pancreatic beta-cell function: A meta-analysis.


ABSTRACT: BACKGROUND AND OBJECTIVE:Dipeptidyl peptidase-4 (DPP-4) inhibitors have been suggested to have pancreatic beta-cell preserving effect according to studies using homeostatic model of assessment for beta-cell function (HOMA-?). However, whether HOMA-? is a suitable biomarker for comparisons between hypoglycemic drugs with different mechanisms of action remains unclear. Therefore, we conducted a meta-analysis to compare the effects of DPP-4 inhibitors and other classes of hypoglycemic drugs on HOMA-? and proinsulin-to-insulin ratio (PIR). METHODS:We searched MEDLINE, CENTRAL, and Ichushi-web for the period of 1966 to May 2020. We collected randomized, controlled clinical trials in patients with type 2 diabetes mellitus comparing DPP-4 inhibitors and other classes of hypoglycemic agents [?-glucosidase inhibitors (?-GIs), glucagon-like peptide-1 (GLP-1) analogues, metformin, sodium-glucose cotransporter 2 (SGLT2) inhibitors, sulfonylureas, or thiazolidinediones]. Weighted mean differences and 95% confidence intervals of changes in HOMA-? or PIR during study periods were calculated for pairwise comparisons. RESULTS:Thirty-seven and 21 relevant trials were retrieved for comparisons of HOMA-? and PIR, respectively. HOMA-? and PIR consistently showed superiority of DPP-4 inhibitors compared with ?-GIs. Both biomarkers consistently supported inferiority of DPP-4 inhibitors compared with GLP-1 analogues. However, PIR showed inferiority of DPP-4 inhibitors compared with metformin, and superiority compared with SGLT2 inhibitors, whereas HOMA-? showed no significant differences between DPP-4 inhibitors and the two other agents. CONCLUSION:DPP-4 inhibitors appear to be superior to ?-GIs but inferior to GLP-1 analogues in preservation of beta-cell function assessed by either HOMA-? or PIR. DPP-4 inhibitors seem to be superior to SGLT2 inhibitors but inferior to metformin on islet function assessed only by PIR. Because HOMA-? and PIR may indicate different aspects of beta-cell function, results of beta-cell function preserving effects of hypoglycemic agents should be interpreted with caution.

SUBMITTER: Takahashi M 

PROVIDER: S-EPMC7380634 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Comparisons between dipeptidyl peptidase-4 inhibitors and other classes of hypoglycemic drugs using two distinct biomarkers of pancreatic beta-cell function: A meta-analysis.

Takahashi Masahiro M   Shibasaki Misa M   Echizen Hirotoshi H   Kushiyama Akifumi A  

PloS one 20200724 7


<h4>Background and objective</h4>Dipeptidyl peptidase-4 (DPP-4) inhibitors have been suggested to have pancreatic beta-cell preserving effect according to studies using homeostatic model of assessment for beta-cell function (HOMA-β). However, whether HOMA-β is a suitable biomarker for comparisons between hypoglycemic drugs with different mechanisms of action remains unclear. Therefore, we conducted a meta-analysis to compare the effects of DPP-4 inhibitors and other classes of hypoglycemic drugs  ...[more]

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