Ontology highlight
ABSTRACT:
SUBMITTER: Dodard G
PROVIDER: S-EPMC7383148 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Dodard Garvin G Tata Angela A Erick Timothy K TK Jaime Diego D Miah S M Shahjahan SMS Quatrini Linda L Escalière Bertrand B Ugolini Sophie S Vivier Eric E Brossay Laurent L
Cell reports 20200701 1
The liver harbors two main innate lymphoid cell (ILC) populations: conventional NK (cNK) cells and tissue-resident NK (trNK) cells. Using the MCMV model of infection, we find that, in contrast to liver cNK cells, trNK cells initially undergo a contraction phase followed by a recovery phase to homeostatic levels. The contraction is MCMV independent because a similar phenotype is observed following poly(I:C)/CpG or α-GalCer injection. The rapid contraction phase is due to apoptosis, whereas the re ...[more]