Ontology highlight
ABSTRACT:
SUBMITTER: Li A
PROVIDER: S-EPMC7384163 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20200525 30
Steroidal C7β alcohols and their respective esters have shown significant promise as neuroprotective and anti-inflammatory agents to treat chronic neuronal damage like stroke, brain trauma, and cerebral ischemia. Since C7 is spatially far away from any functional groups that could direct C-H activation, these transformations are not readily accessible using modern synthetic organic techniques. Reported here are P450-BM3 mutants that catalyze the oxidative hydroxylation of six different steroids ...[more]