Ontology highlight
ABSTRACT:
SUBMITTER: Ricci A
PROVIDER: S-EPMC7384355 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20110121 4
Camptothecin (CPT) derivatives are clinically effective poisons of DNA topoisomerase I (Top1) able to form a ternary complex with the Top1-DNA complex. The aim of this investigation was to examine the dynamic aspects of the ternary complex formation by means of site-directed spin labeling electron paramagnetic resonance (SDSL-EPR). Two semisynthetic CPT derivatives bearing the paramagnetic moiety were synthesized, and their biological activity was tested. A 22-mer DNA oligonucleotide sequence wi ...[more]