Ontology highlight
ABSTRACT:
SUBMITTER: Swaminathan D
PROVIDER: S-EPMC7384537 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Swaminathan Divya D Dickinson George D GD Demuro Angelo A Parker Ian I
Cell calcium 20191218
Cellular Ca<sup>2+</sup> signals are often constrained to cytosolic micro- or nano-domains where stochastic openings of Ca<sup>2+</sup> channels cause large fluctuations in local Ca<sup>2+</sup> concentration (Ca<sup>2+</sup> 'noise'). With the advent of TIRF microscopy to image the fluorescence of Ca<sup>2+</sup>-sensitive probes from attoliter volumes it has become possible to directly monitor these signals, which closely track the gating of plasmalemmal and ER Ca<sup>2+</sup>-permeable channe ...[more]