Ontology highlight
ABSTRACT:
SUBMITTER: Arriola Apelo SI
PROVIDER: S-EPMC7386906 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Arriola Apelo Sebastian I SI Lin Amy A Brinkman Jacqueline A JA Meyer Emma E Morrison Mark M Tomasiewicz Jay L JL Pumper Cassidy P CP Baar Emma L EL Richardson Nicole E NE Alotaibi Mohammed M Lamming Dudley W DW
eLife 20200728
Inhibition of mTOR (mechanistic Target Of Rapamycin) signaling by rapamycin promotes healthspan and longevity more strongly in females than males, perhaps because inhibition of hepatic mTORC2 (mTOR Complex 2) specifically reduces the lifespan of males. Here, we demonstrate using gonadectomy that the sex-specific impact of reduced hepatic mTORC2 is not reversed by depletion of sex hormones. Intriguingly, we find that ovariectomy uncouples lifespan from metabolic health, with ovariectomized female ...[more]