Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing.
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ABSTRACT:
SUBMITTER: Nanki Y
PROVIDER: S-EPMC7387538 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
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Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing.
Nanki Yoshiko Y Chiyoda Tatsuyuki T Hirasawa Akira A Ookubo Aki A Itoh Manabu M Ueno Masaru M Akahane Tomoko T Kameyama Kaori K Yamagami Wataru W Kataoka Fumio F Aoki Daisuke D
Scientific reports 20200728 1
The use of primary patient-derived organoids for drug sensitivity and resistance testing could play an important role in precision cancer medicine. We developed expandable ovarian cancer organoids in < 3 weeks; these organoids captured the characteristics of histological cancer subtypes and replicated the mutational landscape of the primary tumours. Seven pairs of organoids (3 high-grade serous, 1 clear cell, 3 endometrioid) and original tumours shared 59.5% (36.1-73.1%) of the variants identifi ...[more]
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