Ontology highlight
ABSTRACT:
SUBMITTER: Arabnejad M
PROVIDER: S-EPMC7387719 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Arabnejad Marziyeh M Montgomery Courtney G CG Gaffney Patrick M PM McKinney Brett A BA
Frontiers in genetics 20200722
Nearest-neighbor Projected-Distance Regression (NPDR) is a feature selection technique that uses nearest-neighbors in high dimensional data to detect complex multivariate effects including epistasis. NPDR uses a regression formalism that allows statistical significance testing and efficient control for multiple testing. In addition, the regression formalism provides a mechanism for NPDR to adjust for population structure, which we apply to a GWAS of systemic lupus erythematosus (SLE). We also te ...[more]