Ontology highlight
ABSTRACT:
SUBMITTER: Dogan S
PROVIDER: S-EPMC7388159 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Dogan Snjezana S Ng Charlotte K Y CKY Xu Bin B Kumar Rahul R Wang Lu L Edelweiss Marcia M Scott Sasinya N SN Zehir Ahmet A Drilon Alexander A Morris Luc G T LGT Lee Nancy Y NY Antonescu Cristina R CR Ho Alan L AL Katabi Nora N Berger Michael F MF Reis-Filho Jorge S JS
Human pathology 20190401
Salivary duct carcinoma (SDC) is a rare, aggressive malignancy with limited treatment options and poor outcome. Twenty-nine primary resected SDC, including 15 SDC de novo (SDCDN), and 14 SDC ex pleomorphic adenoma (SDCXPA) were subjected to the massive parallel sequencing assay (MSK-IMPACT) targeting 287 to 468 cancer-related genes. TP53 was the most frequently altered gene (69%). TP53 mutations and ERBB2 amplification were more frequent in SDCXPA than in SDCDN (P = .0007 and P = .01, respective ...[more]