Dataset Information

Body mass index and outcome in patients with COVID-19: A dose-response meta-analysis.

ABSTRACT:

Background

There is mounting evidence related to the association between obesity and severity of COVID-19. However, the direct relationship of the increase in the severe COVID-19 risk factors, with an increase in body mass index (BMI), has not yet been evaluated.

Aim

This meta-analysis aims to evaluate the dose-response relationship between body mass index (BMI) and poor outcome in patients with COVID-19.

Methods

A systematic literature search was conducted using PubMed, Europe PMC, ProQuest, and the Cochrane Central Database. The primary outcome was composite poor outcome composed of mortality and severity. The secondary outcomes were mortality and severity.

Results

A total of 34,390 patients from 12 studies were included in this meta-analysis. The meta-analysis demonstrated that obesity was associated with composite poor outcome (OR 1.73 [1.40, 2.14], P<0.001; I²: 55.6%), mortality (OR 1.55 [1.16, 2.06], P=0.003; I²: 74.4%), and severity (OR 1.90 [1.45, 2.48], P<0.001; I²: 5.2%) in patients with COVID-19. A pooled analysis of highest BMI versus reference BMI indicate that a higher BMI in the patients was associated with composite poor outcome (aOR 3.02 [1.82, 5.00], P<0.001; I²: 59.8%), mortality (aOR 2.85 [1.17, 6.92], P=0.002; I²: 79.7%), and severity (aOR 3.08 [1.78, 5.33], P<0.001; I²: 11.7%). The dose-response meta-analysis showed an increased risk of composite poor outcome by aOR of 1.052 [1.028, 1.077], P<0.001 for every 5kg/m² increase in BMI (P_{non-linearity}<0.001). The curve became steeper with increasing BMI.

Conclusion

Dose-response meta-analysis demonstrated that increased BMI was associated with increased poor outcome in patients with COVID-19.

SUBMITTER: Pranata R

PROVIDER: S-EPMC7388778 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Publications

Body mass index and outcome in patients with COVID-19: A dose-response meta-analysis.

Pranata R R Lim M A MA Yonas E E Vania R R Lukito A A AA Siswanto B B BB Meyer M M

Diabetes & metabolism 20200729 2

<h4>Background</h4>There is mounting evidence related to the association between obesity and severity of COVID-19. However, the direct relationship of the increase in the severe COVID-19 risk factors, with an increase in body mass index (BMI), has not yet been evaluated.<h4>Aim</h4>This meta-analysis aims to evaluate the dose-response relationship between body mass index (BMI) and poor outcome in patients with COVID-19.<h4>Methods</h4>A systematic literature search was conducted using PubMed, Eu ...[more]

PMID: 32738402

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Project description:Objective: This study presumed that a high or low body mass index (BMI) might increase the risk of infant mortality. Therefore, a meta-analysis was performed to systematically assess the association between maternal BMI and the risk of infant mortality. Methods: The electronic databases, including Pubmed, Embase database, and Cochrane Library, were systemically searched by two investigators from inception to November 26th, 2020, with no language restriction. In parallel, a dose-response was assessed. Results: Finally, 22 cohort studies involving 13,532,293 participants were included into this paper, which showed that compared with normal BMI, maternal overweight significantly increased the risks of infant mortality [risk ratio (RR), 1.16; 95% confidence interval (CI), 1.13-1.19], neonatal mortality (RR, 1.23; 95% CI, 1.08-1.39), early neonatal mortality (RR, 1.55; 95% CI, 1.26-1.92) and post-neonatal mortality (RR, 1.18; 95% CI, 1.07-1.29). Similarly, maternal obesity significantly increased the risk of infant mortality (RR, 1.55; 95% CI, 1.41-1.70), neonatal mortality (RR, 1.55; 95% CI, 1.28-1.67), early neonatal mortality (RR, 1.37; 95% CI, 1.13-1.67), and post-neonatal mortality (RR, 1.30; 95% CI, 1.03-1.65), whereas maternal underweight potentially decreased the risk of infant mortality (RR, 0.93; 95% CI, 0.88-0.98). In the dose-response analysis, the risk of infant mortality significantly increased when the maternal BMI was >25 kg/m2. Conclusions: Maternal overweight or obesity significantly increases the risks of infant mortality, neonatal mortality, early neonatal mortality, and post-neonatal mortality compared with normal BMI in a dose-dependent manner. Besides, maternal underweight will not increase the risk of infant mortality, neonatal mortality, early neonatal mortality, or postneonatal mortality; instead, it tends to decrease the risk of infant mortality. Early weight management may provide potential benefits to infants, and more large-scale prospective studies are needed to verify this finding in the future.

Dataset Information

Body mass index and outcome in patients with COVID-19: A dose-response meta-analysis.

Background

Aim

Methods

Results

Conclusion

Publications

Body mass index and outcome in patients with COVID-19: A dose-response meta-analysis.

Similar Datasets

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