Ontology highlight
ABSTRACT:
SUBMITTER: Washburn RS
PROVIDER: S-EPMC7390762 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
iScience 20200709 8
It has been known for more than 50 years that transcription and translation are physically coupled in bacteria, but whether or not this coupling may be mediated by the two-domain protein N-utilization substance (Nus) G in Escherichia coli is still heavily debated. Here, we combine integrative structural biology and functional analyses to provide conclusive evidence that NusG can physically link transcription with translation by contacting both RNA polymerase and the ribosome. We present a cryo-e ...[more]