Ontology highlight
ABSTRACT:
SUBMITTER: Ranjan AK
PROVIDER: S-EPMC7391684 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Ranjan Amaresh K AK Briyal Seema S Gulati Anil A
Scientific reports 20200729 1
The development of effective drugs for stroke is urgently required as it is the 2nd largest killer in the world and its incidence is likely to increase in the future. We have demonstrated cerebral endothelin B receptors (ETBR) as a potential target to treat acute cerebral ischemic stroke. However, the mechanism of ETBR mediated neural regeneration and repair remains elusive. In this study, a permanent middle cerebral artery occluded (MCAO) rat model was used. Sovateltide (an ETBR agonist) inject ...[more]