Long non-coding RNAs in regulation of adipogenesis and adipose tissue function.

ABSTRACT: Complex interaction between genetics, epigenetics, environment, and nutrition affect the physiological activities of adipose tissues and their dysfunctions, which lead to several metabolic diseases including obesity or type 2 diabetes. Here, adipogenesis appears to be a process characterized by an intricate network that involves many transcription factors and long noncoding RNAs (lncRNAs) that regulate gene expression. LncRNAs are being investigated to determine their contribution to adipose tissue development and function. LncRNAs possess multiple cellular functions, and they regulate chromatin remodeling, along with transcriptional and post-transcriptional events; in this way, they affect gene expression. New investigations have demonstrated the pivotal role of these molecules in modulat

SUBMITTER: Squillaro T 

PROVIDER: S-EPMC7392603 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature