Ontology highlight
ABSTRACT:
SUBMITTER: Barbosa J
PROVIDER: S-EPMC7392810 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Barbosa Joao J Stein Heike H Martinez Rebecca L RL Galan-Gadea Adrià A Li Sihai S Dalmau Josep J Adam Kirsten C S KCS Valls-Solé Josep J Constantinidis Christos C Compte Albert A
Nature neuroscience 20200622 8
Persistent neuronal spiking has long been considered the mechanism underlying working memory, but recent proposals argue for alternative 'activity-silent' substrates. Using monkey and human electrophysiology data, we show here that attractor dynamics that control neural spiking during mnemonic periods interact with activity-silent mechanisms in the prefrontal cortex (PFC). This interaction allows memory reactivations, which enhance serial biases in spatial working memory. Stimulus information wa ...[more]