Dataset Information

Novel Carbon-Based Magnetic Luminescent Nanocomposites for Multimodal Imaging.

ABSTRACT: Multifunctional nanocomposites can combine multiple functions into a single nanosystem and thus have attracted extensive interest in various fields. The combination of magnetic and upconversion luminescent nanoparticles into one single nanoplatform, which have a good application in biomedical fields such as bio-magnetic separation, magnetic resonance imaging (MRI), and optical imaging, is highly desirable. Here we reported multifunctional nanocomposites by using hollow carbon sphere to integrate magnetic Fe3O4 and upconversion nanoparticles (UCNPs) into one nanosystem. The as-prepared UCNPs/Fe3O4@h-C have near-infrared (NIR) luminescence under 980 nm excitation and superparamagnetism. In addition, since the carbon layer can absorb NIR light and transfer it into heat with high efficiency, the nanocomposites can realize photo thermal (PT), upconversion luminescence (UCL) and MRI tri-mode imaging. The UCNPs/Fe3O4@h-C might be further utilized as a potential theranostic agent, including its in-depth monitoring through luminescent imaging and MRI diagnosis, as well as its direct use in tumors as a photothermal therapy (PTT) agent.

SUBMITTER: Liu F

PROVIDER: S-EPMC7393243 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Novel Carbon-Based Magnetic Luminescent Nanocomposites for Multimodal Imaging.

Liu Fangfang F Mou Xiaoming X Song Jimei J Li Qin Q Liu Jinliang J

Frontiers in chemistry 20200724

Multifunctional nanocomposites can combine multiple functions into a single nanosystem and thus have attracted extensive interest in various fields. The combination of magnetic and upconversion luminescent nanoparticles into one single nanoplatform, which have a good application in biomedical fields such as bio-magnetic separation, magnetic resonance imaging (MRI), and optical imaging, is highly desirable. Here we reported multifunctional nanocomposites by using hollow carbon sphere to integrate ...[more]

PMID: 32793556

Similar Datasets

Project description:Cancer diagnosis and treatment represent an urgent medical need given the rising cancer incidence over the past few decades. Cancer theranostics, namely, the combination of diagnostics and therapeutics within a single agent, are being developed using various anticancer drug-, siRNA-, or inorganic materials-loaded nanocarriers. Herein, we demonstrate a strategy of encapsulating quantum dots, superparamagnetic Fe3O4 nanocrystals, and doxorubicin (DOX) into biodegradable poly(d,l-lactic-co-glycolic acid) (PLGA) polymeric nanocomposites using the double emulsion solvent evaporation method, followed by coupling to the amine group of polyethyleneimine premodified with polyethylene glycol-folic acid (PEI-PEG-FA [PPF]) segments and adsorption of vascular endothelial growth factor (VEGF)-targeted small hairpin RNA (shRNA). VEGF is important for tumor growth, progression, and metastasis. These drug-loaded luminescent/magnetic PLGA-based hybrid nanocomposites (LDM-PLGA/PPF/VEGF shRNA) were fabricated for tumor-specific targeting, drug/gene delivery, and cancer imaging. The data showed that LDM-PLGA/PPF/VEGF shRNA nanocomposites can codeliver DOX and VEGF shRNA into tumor cells and effectively suppress VEGF expression, exhibiting remarkable synergistic antitumor effects both in vitro and in vivo. The cell viability waŝ14% when treated with LDM-PLGA/PPF/VEGF shRNA nanocomposites ([DOX] =25 μg/mL), and in vivo tumor growth data showed that the tumor volume decreased by 81% compared with the saline group at 21 days postinjection. Magnetic resonance and fluorescence imaging data revealed that the luminescent/magnetic hybrid nanocomposites may also be used as an efficient nanoprobe for enhanced T2-weighted magnetic resonance and fluorescence imaging in vitro and in vivo. The present work validates the great potential of the developed multifunctional LDM-PLGA/PPF/VEGF shRNA nanocomposites as effective theranostic agents through the codelivery of drugs/genes and dual-modality imaging in cancer treatment.

Dataset Information

Novel Carbon-Based Magnetic Luminescent Nanocomposites for Multimodal Imaging.

Publications

Novel Carbon-Based Magnetic Luminescent Nanocomposites for Multimodal Imaging.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets