Ontology highlight
ABSTRACT:
SUBMITTER: Yamaguchi N
PROVIDER: S-EPMC7393262 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in oncology 20200724
Vestigial-like family (VGLL) members are mammalian orthologs of <i>vestigial</i> gene in <i>Drosophila</i>, and they consist of four homologs (VGLL1-4). VGLL members have TDU motifs that are binding regions to TEA/ATSS-DNA-binding domain transcription factor (TEAD). Through TDU motifs, VGLL members act as transcriptional cofactors for TEAD. VGLL1-3 have single TDU motif, whereas VGLL4 has two tandem TDU motifs, suggesting that VGLL4 has distinct molecular functions among this family. Although mo ...[more]