A ChIP-chip analysis of E2F family in normal and tumor cells reveals interchangeable roles of E2F family members
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Victor Jin
PROVIDER: E-GEOD-8716 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members.
Xu Xiaoqin X Bieda Mark M Jin Victor X VX Rabinovich Alina A Oberley Mathew J MJ Green Roland R Farnham Peggy J PJ
Genome research 20071001 11
Using ChIP-chip assays (employing ENCODE arrays and core promoter arrays), we examined the binding patterns of three members of the E2F family in five cell types. We determined that most E2F1, E2F4, and E2F6 binding sites are located within 2 kb of a transcription start site, in both normal and tumor cells. In fact, the majority of promoters that are active (as defined by TAF1 or POLR2A binding) in GM06990 B lymphocytes and Ntera2 carcinoma cells were also bound by an E2F. This very close relati ...[more]
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