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Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction.

ABSTRACT: In ST-segment elevation myocardial infarction of both patients and mice, there was a decline in blood eosinophil count, with activated eosinophils recruited to the infarct zone. Eosinophil deficiency resulted in attenuated anti-inflammatory macrophage polarization, enhanced myocardial inflammation, increased scar size, and deterioration of myocardial structure and function. Adverse cardiac remodeling in the setting of eosinophil deficiency was prevented by interleukin-4 therapy.

SUBMITTER: Toor IS

PROVIDER: S-EPMC7393409 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction.

Toor Iqbal S IS Rückerl Dominik D Mair Iris I Ainsworth Rob R Meloni Marco M Spiroski Ana-Mishel AM Benezech Cecile C Felton Jennifer M JM Thomson Adrian A Caporali Andrea A Keeble Thomas T Tang Kare H KH Rossi Adriano G AG Newby David E DE Allen Judith E JE Gray Gillian A GA

JACC. Basic to translational science 20200708 7

In ST-segment elevation myocardial infarction of both patients and mice, there was a decline in blood eosinophil count, with activated eosinophils recruited to the infarct zone. Eosinophil deficiency resulted in attenuated anti-inflammatory macrophage polarization, enhanced myocardial inflammation, increased scar size, and deterioration of myocardial structure and function. Adverse cardiac remodeling in the setting of eosinophil deficiency was prevented by interleukin-4 therapy. ...[more]

PMID: 32760855

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