Ontology highlight
ABSTRACT:
SUBMITTER: Rhett JM
PROVIDER: S-EPMC7393484 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Advances in cancer research 20200709
RAS was identified as a human oncogene in the early 1980s and subsequently found to be mutated in nearly 30% of all human cancers. More importantly, RAS plays a central role in driving tumor development and maintenance. Despite decades of effort, there remain no FDA approved drugs that directly inhibit RAS. The prevalence of RAS mutations in cancer and the lack of effective anti-RAS therapies stem from RAS' core role in growth factor signaling, unique structural features, and biochemistry. Howev ...[more]