Ontology highlight
ABSTRACT:
SUBMITTER: Luo Q
PROVIDER: S-EPMC7393602 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Luo Qianxuan Q Wu Ting T Wu Wenfang W Chen Gong G Luo Xuan X Jiang Liping L Tao Huai H Rong Mingqiang M Kang Shuntong S Deng Meichun M
Frontiers in pharmacology 20200723
Voltage-gated sodium channels (VGSCs), which are abnormally expressed in various types of cancers such as breast cancer, prostate cancer, lung cancer, and cervical cancer, are involved in the metastatic process of invasion and migration. Nav1.5 is a pore-forming α subunit of VGSC encoded by <i>SCN5A</i>. Various studies have demonstrated that Nav1.5, often as its neonatal splice form, is highly expressed in metastatic breast cancer cells. Abnormal activation and expression of Nav1.5 trigger a va ...[more]