Ontology highlight
ABSTRACT:
SUBMITTER: Walker PA
PROVIDER: S-EPMC7395068 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Walker Paul A PA Ryder Stephanie S Lavado Andrea A Dilworth Clive C Riley Robert J RJ
Archives of toxicology 20200506 8
Early identification of toxicity associated with new chemical entities (NCEs) is critical in preventing late-stage drug development attrition. Liver injury remains a leading cause of drug failures in clinical trials and post-approval withdrawals reflecting the poor translation between traditional preclinical animal models and human clinical outcomes. For this reason, preclinical strategies have evolved over recent years to incorporate more sophisticated human in vitro cell-based models with mult ...[more]