Ontology highlight
ABSTRACT:
SUBMITTER: Lidsky PV
PROVIDER: S-EPMC7395509 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Lidsky Peter V PV Andino Raul R
Proceedings of the National Academy of Sciences of the United States of America 20200710 30
Species-specific limits to lifespan (lifespan setpoint) determine the life expectancy of any given organism. Whether limiting lifespan provides an evolutionary benefit or is the result of an inevitable decline in fitness remains controversial. The identification of mutations extending lifespan suggests that aging is under genetic control, but the evolutionary driving forces limiting lifespan have not been defined. By examining the impact of lifespan on pathogen spread in a population, we propose ...[more]