Ontology highlight
ABSTRACT:
SUBMITTER: Zhu R
PROVIDER: S-EPMC7396076 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Mediators of inflammation 20200723
Ventilator-induced lung injury (VILI) is one of the most common complications of mechanical ventilation (MV), which strongly impacts the outcome of ventilated patients. Current evidences indicated that inflammation is a major contributor to the pathogenesis of VILI. Our results showed that MV induced excessive proinflammatory cytokine productions together with decreased CXCL14 and increased PKM2 expressions in injured lungs. In addition, CXCL14 overexpression downregulated PKM2 expression and at ...[more]