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Phase Transition of Huntingtin: Factors and Pathological Relevance.

ABSTRACT: Formation of intracellular mutant Huntingtin (mHtt) aggregates is a hallmark of Huntington's disease (HD). The mechanisms underlying mHtt aggregation, however, are still not fully understood. A few recent studies indicated mHtt undergoes phase transition, bringing new clues to understand how mHtt aggregates assemble. Here in this mini review, we will summarize these findings with a focus on the factors that affect mHtt phase transition. We will also discuss the possible pathological roles of mHtt phase separation in HD.

SUBMITTER: Yang J

PROVIDER: S-EPMC7396480 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Phase Transition of Huntingtin: Factors and Pathological Relevance.

Yang Junsheng J Yang Xiaotong X

Frontiers in genetics 20200723

Formation of intracellular mutant Huntingtin (mHtt) aggregates is a hallmark of Huntington's disease (HD). The mechanisms underlying mHtt aggregation, however, are still not fully understood. A few recent studies indicated mHtt undergoes phase transition, bringing new clues to understand how mHtt aggregates assemble. Here in this mini review, we will summarize these findings with a focus on the factors that affect mHtt phase transition. We will also discuss the possible pathological roles of mHt ...[more]

PMID: 32849783

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