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Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19.

ABSTRACT: Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell membrane fusion process, is composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain that recognizes and binds to the host receptor angiotensin-converting enzyme 2, while the S2 subunit mediates viral cell membrane fusion by forming a six-helical bundle via the two-heptad repeat domain. In this review, we highlight recent research advance in the structure, function and development of antivirus drugs targeting the S protein.

SUBMITTER: Huang Y

PROVIDER: S-EPMC7396720 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19.

Huang Yuan Y Yang Chan C Xu Xin-Feng XF Xu Wei W Liu Shu-Wen SW

Acta pharmacologica Sinica 20200803 9

Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell membrane fusion process, is composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain that recognizes and binds to the host receptor angiotensin-converting enzyme 2, while t ...[more]

PMID: 32747721

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