Dataset Information
Structural conservation among variants of the SARS-CoV-2 spike postfusion bundle
Ontology highlight
ABSTRACT:
SUBMITTER: Axel T Brunger
PROVIDER: EMPIAR-10999 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural conservation among variants of the SARS-CoV-2 spike postfusion bundle.
Proceedings of the National Academy of Sciences of the United States of America 20220401 16
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenge currently available COVID-19 vaccines and monoclonal antibody therapies due to structural and dynamic changes of the viral spike glycoprotein (S). The heptad repeat 1 (HR1) and heptad repeat 2 (HR2) domains of S drive virus–host membrane fusion by assembly into a six-helix bundle, resulting in delivery of viral RNA into the host cell. We surveyed mutations of currently reported SARS-CoV-2 variants and selected eig ...[more]