Ontology highlight
ABSTRACT:
SUBMITTER: Dias-Teixeira K
PROVIDER: S-EPMC7398572 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Dias-Teixeira Karina K Horton Xavier X McKown Robert R Romano Jeffrey J Laurie Gordon W GW
Advances in experimental medicine and biology 20200101
Homeostasis and visual acuity of the surface of the eye are dependent on tears, a thin film comprising at least 1800 different extracellular proteins and numerous species of lipids through which 80% of entering light is refracted at the air interface. Loss of homeostasis in dry eye disease affects 5-7% of the world's population, yet little is known about key molecular players. Our story began as an unbiased screen for regulators of tearing that led to the discovery of homeostasis-restorative 'la ...[more]