Biology of Interleukin-17 and Its Pathophysiological Significance in Sepsis.
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ABSTRACT:
SUBMITTER: Ge Y
PROVIDER: S-EPMC7399097 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Biology of Interleukin-17 and Its Pathophysiological Significance in Sepsis.
Ge Yun Y Huang Man M Yao Yong-Ming YM
Frontiers in immunology 20200728
The interleukin (IL)-17 family includes six structure-related cytokines (A-F). To date, majority of studies have focused on IL-17A. IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. Several recent studies have indicated that IL-17A is a biomarker as well as a therapeutic target in sepsis. In the current review, we summarize the biological functions of IL-17, including IL-17-mediated responses and signal transduction pathways, with part ...[more]
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