Ontology highlight
ABSTRACT:
SUBMITTER: Popescu MR
PROVIDER: S-EPMC7399931 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Popescu Mihaela Roxana MR Dudu Andreea A Jurcut Ciprian C Ciobanu Anca Marina AM Zagrean Ana-Maria AM Panaitescu Anca Maria AM
Diagnostics (Basel, Switzerland) 20200714 7
The presence of maternal Anti-Ro/Anti-La antibodies causes a passively acquired autoimmunity that may be associated with serious fetal complications. The classic example is the autoimmune-mediated congenital heart block (CHB) which is due in most cases to the transplacental passage of Anti-Ro/Anti-La antibodies. The exact mechanisms through which these pathologic events arise are linked to disturbances in calcium channels function, impairment of calcium homeostasis and ultimately apoptosis, infl ...[more]