Mesenchymal Stem Cells Adaptively Respond to Environmental Cues Thereby Improving Granulation Tissue Formation and Wound Healing.
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ABSTRACT:
SUBMITTER: Jiang D
PROVIDER: S-EPMC7403200 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
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Mesenchymal Stem Cells Adaptively Respond to Environmental Cues Thereby Improving Granulation Tissue Formation and Wound Healing.
Jiang Dongsheng D Scharffetter-Kochanek Karin K
Frontiers in cell and developmental biology 20200729
Granulation tissue formation constitutes a key step during wound healing of the skin and other organs. Granulation tissue concomitantly initiates regenerative M2 macrophages polarization, fibroblast proliferation, myofibroblast differentiation with subsequent contraction of the wound, new vessel formation, and matrix deposition. Impaired granulation tissue formation either leads to delayed wound healing or excessive scar formation, conditions with high morbidity and mortality. Accumulating evide ...[more]
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