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Direct and Efficient C(sp3)-H Functionalization of N-Acyl/Sulfonyl Tetrahydroisoquinolines (THIQs) With Electron-Rich Nucleophiles via 2,3-Dichloro-5,6-Dicyano-1,4-Benzoquinone (DDQ) Oxidation.


ABSTRACT: A highly efficient metal-free oxidative direct C(sp3)-H functionalization of N-acyl/sulfonyl 1,2,3,4-tetrahydroisoquinolines (THIQs) with a wide range of electron-rich nucleophiles was accomplished under mild conditions through oxidation with DDQ and subsequent trapping of the resulting reactive and stable N-acyl/sulfonyl iminium ions. The synthetic utility of this method was illustrated by a concise and efficient total synthesis of (±)-benzo[a]quinolizidine (10) in 3 steps from the known N-Cbz 1,2,3,4-THIQ 4b.

SUBMITTER: Yu H 

PROVIDER: S-EPMC7403605 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Direct and Efficient C(sp<sup>3</sup>)-H Functionalization of <i>N</i>-Acyl/Sulfonyl Tetrahydroisoquinolines (THIQs) With Electron-Rich Nucleophiles via 2,3-Dichloro-5,6-Dicyano-1,4-Benzoquinone (DDQ) Oxidation.

Yu Heesun H   Kim Hyoungsu H   Baek Seung-Hoon SH   Lee Dongjoo D  

Frontiers in chemistry 20200729


A highly efficient metal-free oxidative direct C(sp<sup>3</sup>)-H functionalization of <i>N</i>-acyl/sulfonyl 1,2,3,4-tetrahydroisoquinolines (THIQs) with a wide range of electron-rich nucleophiles was accomplished under mild conditions through oxidation with DDQ and subsequent trapping of the resulting reactive and stable <i>N</i>-acyl/sulfonyl iminium ions. The synthetic utility of this method was illustrated by a concise and efficient total synthesis of (±)-benzo[<i>a</i>]quinolizidine (<b>1  ...[more]

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