Ontology highlight
ABSTRACT:
SUBMITTER: Yu H
PROVIDER: S-EPMC7403605 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Yu Heesun H Kim Hyoungsu H Baek Seung-Hoon SH Lee Dongjoo D
Frontiers in chemistry 20200729
A highly efficient metal-free oxidative direct C(sp<sup>3</sup>)-H functionalization of <i>N</i>-acyl/sulfonyl 1,2,3,4-tetrahydroisoquinolines (THIQs) with a wide range of electron-rich nucleophiles was accomplished under mild conditions through oxidation with DDQ and subsequent trapping of the resulting reactive and stable <i>N</i>-acyl/sulfonyl iminium ions. The synthetic utility of this method was illustrated by a concise and efficient total synthesis of (±)-benzo[<i>a</i>]quinolizidine (<b>1 ...[more]