Ontology highlight
ABSTRACT:
SUBMITTER: Barath M
PROVIDER: S-EPMC7404141 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Baráth Marek M Jakubčinová Jana J Konyariková Zuzana Z Kozmon Stanislav S Mikušová Katarína K Bella Maroš M
Beilstein journal of organic chemistry 20200727
A series of ten novel ᴅ-fructofuranosyl and ᴅ-tagatofuranosyl sulfones bearing a 1-<i>O</i>-phosphono moiety and three different substituents at C-2 has been prepared. Due to the structural similarities of these scaffolds to the native substrate of mycobacterial galactofuranosyltransferase GlfT2 in the transition state, we evaluated these compounds by computational methods, as well as in an enzyme assay for the possible inhibition of the mycobacterial galactan biosynthesis. Our data show that de ...[more]