Ontology highlight
ABSTRACT:
SUBMITTER: Blasiak J
PROVIDER: S-EPMC7404247 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Blasiak Janusz J Pawlowska Elzbieta E Chojnacki Jan J Szczepanska Joanna J Chojnacki Cezary C Kaarniranta Kai K
International journal of molecular sciences 20200715 14
Zinc supplementation is reported to slow down the progression of age-related macular degeneration (AMD), but there is no general consensus on the beneficiary effect on zinc in AMD. As zinc can stimulate autophagy that is declined in AMD, it is rational to assume that it can slow down its progression. As melanosomes are the main reservoir of zinc in the retina, zinc may decrease the number of lipofuscin granules that are substrates for autophagy. The triad zinc-autophagy-AMD could explain some co ...[more]