Ontology highlight
ABSTRACT:
SUBMITTER: Naumovska E
PROVIDER: S-EPMC7404294 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Naumovska Elena E Aalderink Germaine G Wong Valencia Christian C Kosim Kinga K Nicolas Arnaud A Brown Stephen S Vulto Paul P Erdmann Kai S KS Kurek Dorota D
International journal of molecular sciences 20200714 14
Intestinal organoids have emerged as the new paradigm for modelling the healthy and diseased intestine with patient-relevant properties. In this study, we show directed differentiation of induced pluripotent stem cells towards intestinal-like phenotype within a microfluidic device. iPSCs are cultured against a gel in microfluidic chips of the OrganoPlate, in which they undergo stepwise differentiation. Cells form a tubular structure, lose their stem cell markers and start expressing mature intes ...[more]