Ontology highlight
ABSTRACT:
SUBMITTER: Meszaros A
PROVIDER: S-EPMC7407516 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Mészáros Ádám Á Molnár Kinga K Nógrádi Bernát B Hernádi Zsófia Z Nyúl-Tóth Ádám Á Wilhelm Imola I Krizbai István A IA
Cells 20200704 7
Aging is characterized by a chronic low-grade sterile inflammation dubbed as inflammaging, which in part originates from accumulating cellular debris. These, acting as danger signals with many intrinsic factors such as cytokines, are sensed by a network of pattern recognition receptors and other cognate receptors, leading to the activation of inflammasomes. Due to the inflammasome activity-dependent increase in the levels of pro-inflammatory interleukins (IL-1β, IL-18), inflammation is initiated ...[more]