Ontology highlight
ABSTRACT:
SUBMITTER: Jin W
PROVIDER: S-EPMC7408920 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Journal of clinical medicine 20200716 7
The erythroblastic leukemia viral oncogene homolog (ErBb) family consists of the receptor tyrosine kinases (RTK) epidermal growth factor receptor (EGFR; also called ERBB1), ERBB2, ERBB3, and ERBB4. This family is closely associated with the progression of cholangiocarcinoma (CC) through the regulation of cellular networks, which are enhanced during tumorigenesis, metastasis, and chemoresistance. Additionally, the constitutive activation of cellular signaling by the overexpression and somatic mut ...[more]