Ontology highlight
ABSTRACT:
SUBMITTER: Filippo Buono M
PROVIDER: S-EPMC7409052 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Filippo Buono Michele M von Boehmer Lisa L Strang Jaan J Hoerstrup Simon P SP Emmert Maximilian Y MY Nugraha Bramasta B
Cells 20200720 7
Genetic cardiomyopathies are characterized by changes in the function and structure of the myocardium. The development of a novel in vitro model could help to better emulate healthy and diseased human heart conditions and may improve the understanding of disease mechanisms. In this study, for the first time, we demonstrated the generation of cardiac organoids using a triculture approach of human induced pluripotent stem-cell-derived cardiomyocytes (hiPS-CMs)-from healthy subjects and cardiomyopa ...[more]