Ontology highlight
ABSTRACT:
SUBMITTER: D'Alterio C
PROVIDER: S-EPMC7409147 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
D'Alterio Crescenzo C Zannetti Antonella A Trotta Anna Maria AM Ieranò Caterina C Napolitano Maria M Rea Giuseppina G Greco Adelaide A Maiolino Piera P Albanese Sandra S Scognamiglio Giosuè G Tatangelo Fabiana F Tafuto Salvatore S Portella Luigi L Santagata Sara S Nasti Guglielmo G Ottaiano Alessandro A Pacelli Roberto R Delrio Paolo P Botti Gerardo G Scala Stefania S
Cancers 20200718 7
The chemokine receptor CXCR4 is overexpressed and functional in colorectal cancer. To investigate the role of CXCR4 antagonism in potentiating colon cancer standard therapy, the new peptide CXCR4 antagonist Peptide R (Pep R) was employed. Human colon cancer HCT116 xenograft-bearing mice were treated with chemotherapeutic agents (CT) 5-Fluorouracil (5FU) and oxaliplatin (OX) or 5FU and radio chemotherapy (RT-CT) in the presence of Pep R. After two weeks, CT plus Pep R reduced by 4-fold the relati ...[more]