Tumor-Associated Macrophage Status in Cancer Treatment.
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ABSTRACT:
SUBMITTER: Malfitano AM
PROVIDER: S-EPMC7409350 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Tumor-Associated Macrophage Status in Cancer Treatment.
Malfitano Anna Maria AM Pisanti Simona S Napolitano Fabiana F Di Somma Sarah S Martinelli Rosanna R Portella Giuseppe G
Cancers 20200721 7
Tumor-associated macrophages (TAMs) represent the most abundant innate immune cells in tumors. TAMs, exhibiting anti-inflammatory phenotype, are key players in cancer progression, metastasis and resistance to therapy. A high TAM infiltration is generally associated with poor prognosis, but macrophages are highly plastic cells that can adopt either proinflammatory/antitumor or anti-inflammatory/protumor features in response to tumor microenvironment stimuli. In the context of cancer therapy, many ...[more]
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