Remdesivir and its antiviral activity against COVID-19: A systematic review.
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ABSTRACT: Background
The aim of this study was to summarize the antiviral activities of remdesivir against SARS-CoV-2, the causative agent of COVID-19.Methods
Available publications were systematically explored on some databases and gray literature was examined. Publications were discussed narratively.Results
Remdesivir inhibits SARS-CoV-2 replication, reduces viral load, and exerts protective effects in SARS-CoV-2 infected animals. Remdesivir also reduces the pathological process, alleviates mild symptoms, and improves pulmonary lesions in SARS-CoV-2-infecetd animals. Remdesivir has been used as a compassionate drug for treating COVID-19 patients.Conclusion
Although remdesivir has shown potent antiviral activities, more efficacy assessments are urgently warranted in clinical trials.
SUBMITTER: Frediansyah A
PROVIDER: S-EPMC7410793 | biostudies-literature | 2021 Jan-Mar
REPOSITORIES: biostudies-literature
Publications
Remdesivir and its antiviral activity against COVID-19: A systematic review.
Frediansyah Andri A Nainu Firzan F Dhama Kuldeep K Mudatsir Mudatsir M Harapan Harapan H
Clinical epidemiology and global health 20200807
<h4>Background</h4>The aim of this study was to summarize the antiviral activities of remdesivir against SARS-CoV-2, the causative agent of COVID-19.<h4>Methods</h4>Available publications were systematically explored on some databases and gray literature was examined. Publications were discussed narratively.<h4>Results</h4>Remdesivir inhibits SARS-CoV-2 replication, reduces viral load, and exerts protective effects in SARS-CoV-2 infected animals. Remdesivir also reduces the pathological process, ...[more]
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