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A promising antiviral candidate drug for the COVID-19 pandemic: A mini-review of remdesivir.

ABSTRACT: Remdesivir (GS-5734), a viral RNA-dependent RNA polymerase (RdRP) inhibitor that can be used to treat a variety of RNA virus infections, is expected to be an effective treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. On May 1, 2020, The U.S. Food and Drug Administration (FDA) has granted Emergency Use Authorization (EUA) for remdesivir to treat COVID-19 patients. In light of the COVID-19 pandemic, this review presents comprehensive information on remdesivir, including information regarding the milestones, intellectual properties, anti-coronavirus mechanisms, preclinical research and clinical trials, and in particular, the chemical synthesis, pharmacology, toxicology, pharmacodynamics and pharmacokinetics of remdesivir. Furthermore, perspectives regarding the use of remdesivir for the treatment of COVID-19 are also discussed.

SUBMITTER: Liang C

PROVIDER: S-EPMC7834743 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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A promising antiviral candidate drug for the COVID-19 pandemic: A mini-review of remdesivir.

Liang Chengyuan C Tian Lei L Liu Yuzhi Y Hui Nan N Qiao Guaiping G Li Han H Shi Zhenfeng Z Tang Yonghong Y Zhang Dezhu D Xie Xiaolin X Zhao Xu X

European journal of medicinal chemistry 20200606

Remdesivir (GS-5734), a viral RNA-dependent RNA polymerase (RdRP) inhibitor that can be used to treat a variety of RNA virus infections, is expected to be an effective treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. On May 1, 2020, The U.S. Food and Drug Administration (FDA) has granted Emergency Use Authorization (EUA) for remdesivir to treat COVID-19 patients. In light of the COVID-19 pandemic, this review presents comprehensive information on remdesivir, ...[more]

PMID: 32563812

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