Ontology highlight
ABSTRACT:
SUBMITTER: Cox MJ
PROVIDER: S-EPMC7411054 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Cox Michael J MJ Jaensch Steffen S Van de Waeter Jelle J Cougnaud Laure L Seynaeve Daan D Benalla Soulaiman S Koo Seong Joo SJ Van Den Wyngaert Ilse I Neefs Jean-Marc JM Malkov Dmitry D Bittremieux Mart M Steemans Margino M Peeters Pieter J PJ Wegner Jörg Kurt JK Ceulemans Hugo H Gustin Emmanuel E Chong Yolanda T YT Göhlmann Hinrich W H HWH
Scientific reports 20200806 1
Phenomic profiles are high-dimensional sets of readouts that can comprehensively capture the biological impact of chemical and genetic perturbations in cellular assay systems. Phenomic profiling of compound libraries can be used for compound target identification or mechanism of action (MoA) prediction and other applications in drug discovery. To devise an economical set of phenomic profiling assays, we assembled a library of 1,008 approved drugs and well-characterized tool compounds manually an ...[more]