Ontology highlight
ABSTRACT:
SUBMITTER: Kim NH
PROVIDER: S-EPMC7412499 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Kim Nam-Hun NH Kim Hong-Ki HK Lee Ji-Hak JH Jo Seung-Il SI Won Hye-Min HM Lee Gyeong-Seok GS Lee Hyoun-Su HS Nam Kung-Woo KW Kim Wan-Jong WJ Han Man-Deuk MD
Molecules (Basel, Switzerland) 20200707 13
The NLRP3 (NACHT, LRR and PYD domains-containing protein 3) inflammasome has been implicated in a variety of diseases, including atherosclerosis, neurodegenerative diseases, and infectious diseases. Thus, inhibitors of NLRP3 inflammasome have emerged as promising approaches to treat inflammation-related diseases. The aim of this study was to explore the effects of juglone (5-hydroxyl-1,4-naphthoquinone) on NLRP3 inflammasome activation. The inhibitory effects of juglone on nitric oxide (NO) prod ...[more]