Repetitive elements as a transcriptomic marker of aging: Evidence in multiple datasets and models.
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ABSTRACT:
SUBMITTER: LaRocca TJ
PROVIDER: S-EPMC7412685 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Repetitive elements as a transcriptomic marker of aging: Evidence in multiple datasets and models.
LaRocca Thomas J TJ Cavalier Alyssa N AN Wahl Devin D
Aging cell 20200605 7
Transcriptomic markers of aging can be useful for studying age-related processes and diseases. However, noncoding repetitive element (RE) transcripts, which may play an important role in aging, are commonly overlooked in transcriptome studies-and their potential as a transcriptomic marker of aging has not been evaluated. Here, we used multiple RNA-seq datasets generated from human samples and Caenorhabditis elegans and found that most RE transcripts (a) accumulate progressively with aging; (b) c ...[more]
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