The relationship between metabolic syndrome and increased risk of Barrett's esophagus: an updated systematic review and meta-analysis.

ABSTRACT: BACKGROUND:The relationship between metabolic syndrome (MetS) and Barrett's esophagus (BE) is still a challenging issue, and inconsistent results have been reported in different studies. Therefore, this study was conducted to determine the relationship between MetS and BE. METHODS:In this study, we followed the MOOSE protocol and results were reported according to the PRISMA guidelines. All study steps were performed independently by two authors. If necessary, the dispute was resolved by consultation with a third author. The search strategy is designed to find published studies. Comprehensive search was done in the following databases until July 2019: Cochrane Library, PubMed/Medline, Web of Science, Science Direct, EMBASE, Scopus, CINAHL, EBSCO, and Google Scholar search engine. All analyses were performed using Comprehensive Meta-Analysis Software Ver.2, while p-value lower than 0.05 was considered significant. RESULTS:In 14 studies with a sample size of 108,416, MetS significantly increased the risk of BE (OR?=?1.354; 95% CI: 1.145-1.600; P?

SUBMITTER: Karimian M 

PROVIDER: S-EPMC7412848 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature