Ontology highlight
ABSTRACT:
SUBMITTER: Zhou X
PROVIDER: S-EPMC7412870 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Zhou Xiang X Wahane Shalaka S Friedl Marie-Sophie MS Kluge Michael M Friedel Caroline C CC Avrampou Kleopatra K Zachariou Venetia V Guo Lei L Zhang Bin B He Xijing X Friedel Roland H RH Zou Hongyan H
Nature neuroscience 20200301 3
Tissue repair after spinal cord injury requires the mobilization of immune and glial cells to form a protective barrier that seals the wound and facilitates debris clearing, inflammatory containment and matrix compaction. This process involves corralling, wherein phagocytic immune cells become confined to the necrotic core, which is surrounded by an astrocytic border. Here we elucidate a temporally distinct gene signature in injury-activated microglia and macrophages (IAMs) that engages axon gui ...[more]