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Ca2+ as a therapeutic target in cancer.

ABSTRACT: Ca2+ is a ubiquitous and dynamic second messenger molecule that is induced by many factors including receptor activation, environmental factors, and voltage, leading to pleiotropic effects on cell function including changes in migration, metabolism and transcription. As such, it is not surprising that aberrant regulation of Ca2+ signals can lead to pathological phenotypes, including cancer progression. However, given the highly context-specific nature of Ca2+-dependent changes in cell function, delineation of its role in cancer has been a challenge. Herein, we discuss the distinct roles of Ca2+ signaling within and between each type of cancer, including consideration of the potential of therapeutic strategies targeting these signaling pathways.

SUBMITTER: Gross S 

PROVIDER: S-EPMC7412871 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Ca<sup>2+</sup> as a therapeutic target in cancer.

Gross Scott S   Mallu Pranava P   Joshi Hinal H   Schultz Bryant B   Go Christina C   Soboloff Jonathan J  

Advances in cancer research 20200709

Ca<sup>2+</sup> is a ubiquitous and dynamic second messenger molecule that is induced by many factors including receptor activation, environmental factors, and voltage, leading to pleiotropic effects on cell function including changes in migration, metabolism and transcription. As such, it is not surprising that aberrant regulation of Ca<sup>2+</sup> signals can lead to pathological phenotypes, including cancer progression. However, given the highly context-specific nature of Ca<sup>2+</sup>-dep  ...[more]

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