Ontology highlight
ABSTRACT:
SUBMITTER: Liao C
PROVIDER: S-EPMC7413243 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Liao Calwing C Sarayloo Faezeh F Vuokila Veikko V Rochefort Daniel D Akçimen Fulya F Diamond Simone S Houle Gabrielle G Laporte Alexandre D AD Spiegelman Dan D He Qin Q Catoire Hélène H Dion Patrick A PA Rouleau Guy A GA
Frontiers in genetics 20200731
<b>Objective:</b> Essential tremor (ET) is a common movement disorder that has a high heritability. A number of genetic studies have associated different genes and loci with ET, but few have investigated the biology of any of these genes. <i>STK32B</i> was significantly associated with ET in a large genome-wide association study (GWAS) and was found to be overexpressed in ET cerebellar tissue. The objective of this study is to determine the effects of overexpressed <i>STK32B</i> in cerebellar DA ...[more]